FREN
Dr. Guillaume Beyrend-Frizon
Physician · MD-PhD · Researcher

Dr. Guillaume Beyrend-Frizon

I translate medical jargon into plain English, and I keep at it until it gives in. I can also, reassuringly, tell a stethoscope from a soup spoon.

Physician in Switzerland · Cytometry trainer at HUG (Geneva) · PhD in tumor immunology (Leiden) · Creator of the Cytofast R package · Editor at Frontiers in Immunology

I'm a physician in Switzerland and a doctor of science. My core work is to make the complex legible: turning cutting-edge medicine and science into something useful and clear — for a patient who wants to understand, a colleague who wants to save time, or a scientist who wants to analyze their data.

PhD + storytelling + AI fluency: that combination is what bridges it all.

Four projects, clinical tools, one foundation

It all starts from the same idea — and it's all connected.

Tools I build

Not content — decision instruments, free, built for daily practice.

Where I come from, my expertise

Background

PhD in tumor immunology
Leiden University Medical Center (LUMC), Netherlands
Editor
Frontiers in Immunology
Creator of the Cytofast package
Flow and mass cytometry analysis in R
Trainer in cytometry data analysis
Geneva University Hospitals (HUG)
Physician
Practicing in Switzerland

Areas of expertise

Tumor immunology Immunotherapy Mass cytometry (CyTOF) Single-cell analysis R bioinformatics AI integration Medical science writing
13
Peer-reviewed publications
1000+
Scientists trained
3
Major pharma collaborations
MD-PhD
Tumor immunology · Leiden

How I can help

🤖 AI in medical practice

Implementing AI tools in a practice or hospital department: automating admin, designing custom workflows, freeing up clinical time.

🔬 Cytometry & single-cell analysis

Panel design, high-dimensional analysis in R, clinical trial and biomarker support for pharma, biotech and academic teams.

See my cytometry consulting →

🧭 Making science decidable

For journalists or non-specialist teams: making a study, a technology or a case understandable — and actionable.

✍️ Content & science writing

Editorial strategy, writing, medical website redesign. Proof by example: comprendre-sante.org and urgences-ia.ch.

My PhD thesis

Thesis cover: High-Dimensional Profiling of Immunotherapy-Responsive Immune Cells in Cancer

High-Dimensional Profiling of Immunotherapy-Responsive Immune Cells in Cancer

PhD thesis · Tumor immunology
Leiden University Medical Center (LUMC) · 2021
📄 Read the thesis (PDF · 16 MB)

13 peer-reviewed publications

2026Frontiers in ImmunologyEditorial: Mechanisms and therapeutic opportunities of T-cell impairment in cancer immunity and immunotherapy. 2023Clinical RheumatologySpondyloarthritis mass cytometry immuno-monitoring: a proof of concept study in the TiCoSpA trial. 2023Cell Reports MedicineOX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum. 2022Nature CommunicationsA third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection. 2022Frontiers in ImmunologyIdentification of a Disease-Associated Network of Intestinal Immune Cells in Treatment-Naive Inflammatory Bowel Disease. 2021Arthritis Research & TherapyImmunoprofiling of early rheumatoid arthritis using mass cytometry reveals an activated basophil subset inversely linked to ACPA status. 2021iScienceMemory CD8 T cell heterogeneity is primarily driven by pathogen-specific cues and additionally shaped by the tissue environment. 2020Frontiers in ImmunologyVisualizing Dynamic Changes at the Maternal-Fetal Interface Throughout Human Pregnancy by Mass Cytometry. 2020J. ImmunoTherapy of CancerHost genetics and tumor environment determine the functional impact of neutrophils in mouse tumor models. 2019JoVEVisualization and Quantification of High-Dimensional Cytometry Data using Cytofast, FlowSOM and Cytosplore. 2019J. ImmunoTherapy of CancerPD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors. 2018Comput. Struct. Biotech. J.Cytofast: a workflow for visual and quantitative analysis of flow and mass cytometry data. 2018F1000ResearchCytomegalovirus infection and progressive differentiation of effector-memory T cells.

A project, a question, an idea?

Every collaboration is different. Tell me your context, your question and your timeline — and we'll find the best way to work together.

✉ Write to me